Dominate can be attempted on a lower-generation vampire, but the difficulty raises by 1 for each level of difference between the two (max of 10). The user must also score a minimum of 3 successes against their target, rather than just 1 to be even a little effective.

All supernatural (Awakened) creatures can spend Willpower to negate Dominate for a round. The exceptions to this are: weak-willed, blood bonded, or if the command actually is in tune with the character’s Nature.